Salvage Radiotherapy of Prostate Cancer: A Retrospective Analysis of 10 years’ Experience in the Department of Oncology and Radiotherapy, University Hospital of Split.

Tomislav Omrčen¹, Sebastian Radošević²
1Department of Oncology and Radiotherapy, University Hospital of Split
2University of Split, School of Medicine

Prostate cancer is a common problem in males, especially with advanced age. Patients treated with radical prostatectomy (RP) can develop a biochemical relapse (BR) which can be treated with salvage radiotherapy (SRT).

We retrospectively evaluated the clinical outcome of patients treated with SRT after RP and BR regarding the biochemical relapse-free survival (BRFS), metastasis-free survival (MFS) and overall survival (OS).

Materials and Methods
A retrospective cohort study (from 2006 until 2015) using the data collected from patients’ charts in the Department of Oncology and Radiotherapy in Split. A total of 124 patients treated with SRT after RP and BR were included into this study.

The median follow-up was 58 months with 68 years being the median age of the patients. Out of the 124 patients, 68 (55%) started SRT with a PSA level below 0.7 ng/ml. Eighty patients (65%) responded to SRT with drop in PSA of more than 90%. PSA progression after SRT was observed in 33 patients (27%) and 4 patients (3%) developed metastases. This leads to a median BRFS of 26 months, median MFS of 52.5 months and median OS of 53 months. The 5-year survival rate was 91.7%. A relationship was shown between lymphovascular invasion and MFS (P = 0.015) and OS (P=0.005). Perineural invasion (P = 0.034) and the TNM stage (P = 0.047) show a relation to OS.

Patients treated with SRT show a good biochemical response and excellent disease control in terms of MFS and OS.