Salvage Radiotherapy of Prostate Cancer: A Retrospective Analysis of 10 years’ Experience in the Department of Oncology and Radiotherapy, University Hospital of Split.
Tomislav Omrčen¹, Sebastian Radošević²
1Department of Oncology and Radiotherapy, University Hospital of Split
2University of Split, School of Medicine
Introduction
Prostate cancer is a common problem in males, especially with advanced age. Patients treated with radical prostatectomy (RP) can develop a biochemical relapse (BR) which can be treated with salvage radiotherapy (SRT).
Objectives
We retrospectively evaluated the clinical outcome of patients treated with SRT after RP and BR regarding the biochemical relapse-free survival (BRFS), metastasis-free survival (MFS) and overall survival (OS).
Materials and Methods
A retrospective cohort study (from 2006 until 2015) using the data collected from patients’ charts in the Department of Oncology and Radiotherapy in Split. A total of 124 patients treated with SRT after RP and BR were included into this study.
Results
The median follow-up was 58 months with 68 years being the median age of the patients. Out of the 124 patients, 68 (55%) started SRT with a PSA level below 0.7 ng/ml. Eighty patients (65%) responded to SRT with drop in PSA of more than 90%. PSA progression after SRT was observed in 33 patients (27%) and 4 patients (3%) developed metastases. This leads to a median BRFS of 26 months, median MFS of 52.5 months and median OS of 53 months. The 5-year survival rate was 91.7%. A relationship was shown between lymphovascular invasion and MFS (P = 0.015) and OS (P=0.005). Perineural invasion (P = 0.034) and the TNM stage (P = 0.047) show a relation to OS.
Conclusion
Patients treated with SRT show a good biochemical response and excellent disease control in terms of MFS and OS.